A Brief Review on the Advancement of the Molecular and Serological Diagnosis of SARS-CoV-2

The novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has introduced as causative agent for coronavirus disease 2019 (COVID-19) since the 2019 December. Human coronaviruses are classified in Nidovirales order and Coronavirdiae family. This family includes four genera. The SARS-CoV-2 is a member of Betacoronavirus genera and Sarbecovirus linage (linage B). There is a great number of conducted researches for the therapeutic options, epidemiological aspects, clinical and radiological features and molecular or serological diagnosis for the SARS-CoV-2. There is a verity of the commercially available serological and molecular kits for COVID-19 diagnosis. Also, the WHO recommended molecular approaches for the diagnosis. This recommended list contains different primer and probe sets for SARS-CoV-2 diagnosis and different authors assessed the specificity and sensitivity of this primer and probe sets. In this review, we tried to gather comprehensive information about these diagnosis strategies. Also, there are some studies focused on the antibody response to SARS-CoV-2. By considering the growing amount of the available researches in the field of the serological and molecular diagnosis in SARS-CoV-2 detection, current study was aimed to briefly review the most important advancements in this particular subject area.